ENThere is emphasized that changing environment for business precondition different and complicated conditions for practical activity, also changes of theoretical concepts of phenomena, objects and etc. Entrepreneurship is not an exception. Knowledge-based economy (KBE) raises new challenges for business from practical viewpoint. Theoretically solved practical business questions take a new context and essence. The formed preconditions allow revealing scientifi c research problem of this article: how entrepreneurship concept is perceived in entrepreneurial enterprises in Lithuania; how managers of enterprises perceive entrepreneurship concept in regional science park of Kaunas University of Technology (KTU), incubating more or less entrepreneurial enterprises. The aim of the article is to perform the research by interviewing managers of regional science park of KTU enterprises, in order to clarify the theoretical defi nition of entrepreneurship concept in KBE. Research is based on theoretically grounded considerations on entrepreneurship concept. Research implementation method is interview. Interview results are based on revealing important and non-important characteristics of entrepreneurship concept by perception of enterprises’ managers of regional science park of KTU. The most important implication of research is that enterprises of regional science park of KTU are considered as highly entrepreneurial. Managers of those enterprises are able to make valuable considerations on entrepreneurship concept. Research is valuable as clarifying entrepreneurship concept in KBE from practical business positions. [From the publication]