ENBackground: The COVID-19 pandemic demanded exceptional physical andmental effort fromhealthcareworkers worldwide. Since healthcare workers often refrain from seeking professional psychological support, internetdelivered interventions could serve as a viable alternative option. Objective:Weaimed to investigate the effects of a therapist-guided six-week CBT-based internet-delivered stress recovery intervention amongmedical nurses using a randomized controlled trial design.Wealso aimed to assess program usability. Methods: 168 nursesworking in a healthcare setting (Mage=42.12, SDage=11.38; 97 % female)were included in the study. The intervention group included 77 participants, and thewaiting list control group had 91 participants. Self-report data were collected online at three timepoints: pre-test, post-test, and three-month follow-up. The primary outcome was stress recovery. Secondary outcomes included measures of perceived stress, anxiety and depression symptoms, psychological well-being, posttraumatic stress and complex posttraumatic stress symptoms, and moral injury. Results: We found that the stress recovery intervention FOREST improved stress recovery, including psychological detachment (d = 0.83 [0.52; 1.15]), relaxation (d = 0.93 [0.61, 1.25]), mastery (d = 0.64 [0.33; 0.95]), and control (d=0.46 [0.15; 0.76]). The effects on psychological detachment, relaxation, and mastery remained stable at the three month follow-up. The intervention was also effective in reducing its users' stress (d = −0.49 [−0.80; −0.18]), anxiety symptoms (d = −0.31 [−0.62; −0.01]), depression symptoms (d = −0.49 [−0.80; −0.18]) and increasing psychological well-being (d = 0.53 [0.23; 0.84]) with the effects on perceived stress, depression symptoms, and well-being remaining stable at the three-month follow-up. High user satisfaction and good usability of the intervention were also reported.Conclusions: The present study demonstrated that an internet-based intervention for healthcare staff could increase stress recovery skills, promote psychological well-being, and reduce stress, anxiety, and depression symptoms, with most of the effects being stable over three months. Keywords: Efficacy; Internet-based intervention; Nurses RCT; Stress recovery. [From the publication]