ENIn the Grand Duchy of Lithuania, with the formation of the state society and the emergence of the apparatus of power at the end of the 15th century and at the beginning of the 16th century, the need for writing arose. At the beginning of the 16th century, greater demand for texts was shown by users of Slavic rather than Latin books, which resulted in the establishment of the first printing house in Vilnius - Franciszek Skoryna. Around 1520, Skoryna brought a printing workshop from Prague to Vilnius and brought Cyrillic printing to the territory of the Grand Duchy of Lithuania. The needs of the Orthodox Church were first of all realized by the Mamonich brothers' printing house, and then the printing house of the Orthodox brotherhood of St. The spirit. Cyrillic prints based on the typography of the Mammonchs and the brotherhood of Holy Spirit, they were in great demand by Orthodox believers in Vilnius and the Grand Duchy of Lithuania. Keywords: Vilnius, printing houses, Orthodox Church, Grand Duchy of Lithuania. [From the publication]